XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
  AIDS
  Influenza
  MRSA
  Tuberculosis
  Shigella
  HCV
  SARS
  Ebola
  Dengue
  Malaria
  Pertussis
  Mumps
  Prion Diseases
  Small Pox
  Anthrax
  Leishmaniasis
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
 
 India
Search

Last Updated: Nov 18, 2006 - 12:32:53 PM

AIDS Channel
subscribe to AIDS newsletter

Latest Research : Infectious Diseases : AIDS

   DISCUSS   |   EMAIL   |   PRINT
HIV disease model details survival benefits of HIV therapies
Jun 3, 2006 - 8:48:00 AM, Reviewed by: Dr. Priya Saxena

"As new HIV therapies have come into the clinic, we have witnessed the transformation of HIV/AIDS from a rapidly fatal disease into a controllable condition,"

 
Increasingly effective HIV therapy--including a decade of highly active antiretroviral therapy (HAART)--has provided 3 million years of extended life to Americans with AIDS since 1989, report researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

Rochelle Walensky, M.D., M.P.H., Kenneth Freedberg, M.D., M.Sc., and their colleagues calculated that advances in HIV care have yielded a total survival benefit of 2.8 million years in the United States. The researchers also estimate that drugs to prevent mother-to-child transmission of HIV have averted 2,900 infant infections, saving an additional 137,000 years of life. The model projected that a person initiating HIV therapy in 2003 could expect to live more than 13 years longer than if he or she had been diagnosed in 1988.

The paper by Drs. Walensky and Freedberg, of Massachusetts General Hospital and the Harvard Medical School Center for AIDS Research, and their coauthors has been posted online by The Journal of Infectious Diseases.

"Since the early 1980s, soon after the first reports of what we now know as AIDS, NIH has devoted $30 billion to HIV/AIDS research," says NIH Director Elias A. Zerhouni, M.D. "This study clearly shows the dramatic impact that sustained investment in biomedical research can have in improving the lives of Americans."

"As new HIV therapies have come into the clinic, we have witnessed the transformation of HIV/AIDS from a rapidly fatal disease into a controllable condition," notes NIAID Director Anthony S. Fauci, M.D. "Although the rate of new infections in this country remains unacceptably high, for many people, HIV infection is no longer the death sentence it once was." "Advances in HIV/AIDS treatments have been striking, particularly over the past decade. Our goal in this study was to quantify the clinical progress in AIDS care in terms of years of life saved," says Dr. Walensky.

The researchers used a computer model, developed by Dr. Freedberg and colleagues, that incorporates literature-based data of clinical measures including HIV viral load, CD4+ T-cell counts (a measure of immune system health), efficacy of HAART, and incidence of opportunistic infections, to simulate HIV disease progression both with and without treatment. Information about the number of people diagnosed with AIDS and accessing health care each year between 1989 and 2003 came from U.S. Centers for Disease Control and Prevention surveillance and other published data.

The investigators defined six eras of AIDS treatment between 1989 and 2003. In the first two periods, 1989 to 1992 and 1993 to 1995, drugs became available to prevent two common infections--Pneumocyctis jirovecii pneumonia and Mycobacterium avium complex. Although the drugs provided an average per-person survival benefit during that time of only 2.6 months, those early eras helped to shape the perception that AIDS was a treatable condition, notes Dr. Freedberg. Drs. Walensky and Freedberg subdivided the HAART era, which began in 1996, into four periods corresponding to increasingly effective HAART and other advances in HIV care.

For each year of the six eras, the investigators ran simulations of HIV disease progression in two equal-sized groups of hypothetical people with AIDS. One group received no therapy, while the other group received all available therapies of that era. The model calculated a per-person survival benefit and a total survival benefit in each era. By 2003, the model projected that an individual beginning treatment that year could expect to live more than 13 years longer than if he or she had been diagnosed in 1988. The total survival benefit for the 24,780 people diagnosed with AIDS and entering care in 2003 was 330,189 years. The total cumulative survival benefit across all eras from all forms of HIV therapy was 2.8 million years.

Dr. Walensky emphatically notes, however, that survival benefits related to therapy are available only to those with known HIV infection. But about one-fourth of people in the United States infected with HIV are unaware of their infection, she adds. "We calculated that a cohort of patients presenting with AIDS at higher CD4 cell counts--simulating slightly earlier entry into care--had an additional gain of 740,000 years of survival," says Dr. Walensky. "These findings underscore the importance of expanded HIV testing and better linkage to care for people who are HIV-infected, so that more of them can realize the life-extending benefits of HIV therapies."

"This type of research can also be used to understand the tremendous survival benefits that can be gained globally by continued rapid expansion of access to these very effective HIV/AIDS treatments in resource-limited settings," adds Dr. Freedberg. "This expansion is of critical importance."
 

- RP Walensky et al. The survival benefits of AIDS treatment in the United States. The Journal of Infectious Diseases. Published online June 1, 2006.
 

www.journals.uchicago.edu/JID/journal/issues/v194n1/35845/35845.html

 
Subscribe to AIDS Newsletter
E-mail Address:

 

The National Institute on Drug Abuse and the National Institute of Mental Health, parts of the NIH, also provided support for this research.

NIAID is a component of the National Institutes of Health. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on basic immunology, transplantation and immune-related disorders, including autoimmune diseases, asthma and allergies.

The National Institutes of Health (NIH)--The Nation's Medical Research Agency--includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.


Related AIDS News

Keeping A3G in action represents a new way to attack HIV
Fighting HIV With HIV Virus Itself
HIV exploits competition among T-cells
Harmless GB Virus type C (GBV-C) protects against HIV infection
Study defines effective microbicide design for HIV/AIDS prevention
HIV depends on human p75, study shows
Simplified treatment of HIV infection shows promise
Clinical trial evaluates first-line approaches for treating HIV
T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
B cells with special protein direct HIV to T cells


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us