Blood
Risk of Lymphoma Higher Among People With Family History of Hematopoietic Malignancy
By Journal of the National Cancer Institute
Oct 5, 2005 - 4:17:00 AM

A new study has confirmed the association between family history of hematopoietic malignancy--cancers of the blood or bone marrow, such as leukemia and lymphoma--and the most common types of lymphoma.

Because a family history of hematopoietic malignancy is associated with an increased risk of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma but the magnitude of the risk is unclear, Ellen T. Chang, Sc.D., of the Karolinska Institute in Stockholm, Sweden, and colleagues estimated the association between familial hematopoietic cancer and risk of lymphoma using validated family data from the Swedish Multi-Generation Register and Cancer Register.

They found that a history of hematopoietic malignancy in any first-degree relative was associated with an approximately two-fold increased risk of all NHL, common B-cell NHL subtypes, and Hodgkin lymphoma. The associations between certain environmental factors and lymphoma risk did not vary between individuals with and without familial hematopoietic malignancy.

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