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Last Updated: Nov 18, 2006 - 12:32:53 PM |
Latest Research
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Pharmacotherapy
Genomic signatures to guide the use of chemotherapeutics
Scientists at Duke University's Institute for Genome Sciences & Policy have developed a panel of genomic tests that analyzes the unique molecular traits of a cancerous tumor and determines which chemotherapy will most aggressively attack that patient's cancer.
Oct 23, 2006 - 6:59:00 PM
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CDK2/FOXO1 as drug target to Prevent Tumors
Mayo Clinic researchers have found that a protein that initiates a "quality control check" during cell division also directs cell death for those cells damaged during duplication. This knowledge represents a potential "bulls eye" for targeting anti-tumor drugs. The findings appear in the current issue of Science.
Oct 13, 2006 - 1:11:00 AM
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Telomerase inhibitors may revolutionize cancer therapy
A new target for cancer therapy has been identified by Monash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer development.
Sep 21, 2006 - 8:19:00 PM
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First ever shots of the cervical cancer vaccine administered in Queensland
UQ Professor Ian Frazer administered the first shots of the cervical cancer vaccine Gardasil in Queensland this afternoon at the Princess Alexandra Hospital.
Aug 29, 2006 - 3:41:00 AM
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Gleevec can be toxic to the heart
Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart. Not only that, but other similarly based drugs � called tyrosine kinase inhibitors � could lead to heart problems as well, say researchers at the Center for Translational Medicine at Jefferson Medical College in Philadelphia.
Jul 24, 2006 - 7:27:00 PM
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Anti-cancer possibilities seen for certain monoamine oxidase inhibitors
In 2005, professor Ramin Shiekhattar, Ph.D., at The Wistar Institute and his colleagues reported details about an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells.
Jun 24, 2006 - 4:25:00 PM
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AS101 protects the testis from the effects of paclitaxel
It may be possible to protect the testes of cancer patients against the loss of fertility caused by chemotherapy, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic on Tuesday 20 June 2006. Mr. Alon Carmely from Bar-Ilan University, Ramat Gan, Israel, said that his work showed for the first time that the injection of a drug that enhances the immune system could protect the testis from the effects of paclitaxel (Taxol), a widely used chemotherapy drug.
Jun 20, 2006 - 9:30:00 PM
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Radiotherapy
Microbeam Radiation Therapy (MRT) Could Improve Cancer Treatment
Researchers at the U.S. Department of Energy�s Brookhaven National Laboratory and colleagues at Stony Brook University, the IRCCS NEUROMED Medical Center in Italy, and Georgetown University say improvements they have made to an experimental form of radiation therapy that has been under investigation for many years could make the technique more effective and eventually allow its use in hospitals. Results on the improved method, which was tested in rats, will be published online this week by the Proceedings of the National Academy of Sciences.
Jun 10, 2006 - 1:38:00 PM
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Novel EGFR antibody mAb 806 targets tumors but not normal tissues
The Ludwig Institute for Cancer Research (LICR) and Life Science Pharmaceuticals (LSP) today announced the results of the first clinical trial of monoclonal antibody (mAb) 806, which demonstrate that 806 specifically targets epidermal growth factor receptor (EGFR) on a wide range of tumor types but has no uptake by normal tissues. This result is markedly different to other mAbs, which target wild-type (wt) EGFR on normal tissues.
Jun 6, 2006 - 2:41:00 PM
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Oral chemotherapy option soon for cancer
Swiss pharmaceutical major Roche's study investigating Xeloda (capecitabine) in the first-line treatment of advanced stomach cancer has successfully met its primary endpoint, the company said Monday.
Apr 18, 2006 - 7:20:00 AM
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Cancer
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Radiotherapy
Radiotherapy timings for colon cancer may need adjustments
Scientists have unexpectedly discovered that mice with the gene defect that causes colon cancer in humans can differ from normal mice in how they respond to radiation treatments. The large intestine carrying the gene defect in mice that received staggered doses of radiation was three to four times more resistant to the radiation than in control mice.
Apr 9, 2006 - 9:58:00 AM
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Fibrasorb - New device that could cut chemotherapy deaths
A new method of delivering chemotherapy to cancer patients without incurring side effects such as hair loss and vomiting is being developed. The method, produced at the University of Bath, England, involves using tiny fibres and beads soaked in the chemotherapy drug which are then implanted into the cancerous area in the patient's body.
Apr 3, 2006 - 7:21:00 AM
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Serendipity versus planning - cancer drugs of the future?
New anticancer drugs are usually developed specially for the job, but occasionally they are borrowed from another field of medicine, and applied speculatively in cancer. Tamoxifen was designed as an anti-oestrogen, based on the observation that at least a third of breast cancers depend on female sex hormones such as oestrogen for survival. Tamoxifen has shown to be an exceptionally effective molecule in cancer treatment; It was never planned to be a preventive agent, but so it has proved to be! It is now licensed to be used to prevent breast cancer in certain women at high risk of the disease.
Mar 27, 2006 - 4:29:00 AM
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Vaccination
Scientists one step closer to cancer vaccine
Scientists at Karolinska Institutet in Sweden have helped to identify a molecule that can be used as a vaccination agent against growing cancer tumours. Although the results are so far based on animal experiments, they point to new methods of treating metastases.
Mar 22, 2006 - 1:42:00 AM
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Cancer
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Possibility of Separating Anticancer Properties of Vitamin D Revealed
At the right dose, vitamin D is important for bone development and may help protect against the development of several cancers, particularly colorectal cancer. However, large quantities designed to exploit the vitamin�s anticancer properties can lead to a toxic overdose of calcium in the blood. Now, research done at Georgetown University�s Lombardi Comprehensive Cancer Center indicates that it may be possible to separate the anticancer properties of vitamin D from its other functions.
Mar 19, 2006 - 8:49:00 PM
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Cancer
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Vitamin D can be modified to produce only anti cancer effects
At the right dose, vitamin D is important for bone development and may help protect against the development of several cancers, particularly colorectal cancer. However, large quantities designed to exploit the vitamin�s anticancer properties can lead to a toxic overdose of calcium in the blood. Now, research done at Georgetown University�s Lombardi Comprehensive Cancer Center indicates that it may be possible to separate the anticancer properties of vitamin D from its other functions.
Mar 18, 2006 - 2:07:00 AM
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Cancer
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Pharmacotherapy
Sunitinib Approved for Gastrointestinal Stromal Tumors (GIST) and Kidney Cancer
The Food and Drug Administration (FDA) today announced approval of Sutent (sunitinib), a new targeted anti-cancer treatment for patients with gastrointestinal stromal tumors (GIST), a rare stomach cancer, and advanced kidney cancer. Today's action marks the first time the agency has approved a new oncology product for two indications simultaneously.
Jan 28, 2006 - 12:29:00 PM
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Cancer
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AKT blocks cancer cell motility
In investigating the molecular mechanisms of cancer cell motility – the unique property that enables cancer to spread from its primary origin to other parts of the body – researchers have uncovered a surprising role for the AKT/PKB (protein kinase B) enzyme, providing important new insights into cancer metastasis and suggesting that current efforts to develop cancer therapies by inhibiting AKT may be inadvertently promoting the spread of the disease.
Nov 23, 2005 - 4:57:00 AM
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Cetuximab to be Considered for the Treatment of Squamous Cell Carcinoma of the Head and Neck
ImClone Systems Incorporated and Bristol-Myers Squibb Company announced today that the U.S. Food and Drug Administration (FDA) has notified ImClone Systems that it has accepted for filing the Company's supplemental Biologics License Application (sBLA) for ERBITUX(R) (Cetuximab), an IgG1 monoclonal antibody, in the treatment of Squamous Cell Carcinoma of the Head and Neck (SCCHN).
Nov 1, 2005 - 2:18:00 AM
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How antigen presenting cells are crucial to graft-versus-leukemia's cancer-killing effect
Researchers at the University of Michigan's Comprehensive Cancer Center have discovered the secret weapon behind the most powerful form of cancer immunotherapy known to medicine.
Oct 17, 2005 - 7:30:00 PM
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Cranberry Compound Can Prevent Metastasis
Scientists have discovered a new compound in cranberries that works in a completely new way to prevent metastasis, the spread of cancer to other parts of the body.
Oct 17, 2005 - 7:25:00 PM
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Vaccination
Response to Cancer Vaccine Enhanced by Chemotherapy
A study of a cancer vaccine in mice has found that the vaccine induces a tumor-specific immune response that is enhanced when used with chemotherapy regimens that include 5-fluorouracil (5-FU).
Oct 5, 2005 - 4:17:00 AM
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Cancer
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Marine toxins can knock out the cancer cells
Vibrantly colored creatures from the depths of the South Pacific Ocean harbor toxins that potentially can act as powerful anti-cancer drugs, according to research findings from University of Wisconsin-Madison biochemists and their Italian colleagues.
Sep 28, 2005 - 7:59:00 AM
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Cancer
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"Hitchhiking" Viruses as Cancer Drug Delivery System
A Mayo Clinic research team has devised a new virus-based gene therapy delivery system to help fight cancer. Researchers say their findings will help overcome hurdles that have hindered gene therapy cancer treatments.
Sep 19, 2005 - 12:40:00 PM
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Cancer
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Pegfilgrastim Significantly Reduces the Incidence of Febrile Neutropenia
Amgen (Nasdaq: AMGN), the world's largest biotechnology company, today announced that the U.S. Food and Drug Administration (FDA) approved an update to the Neulasta(R) (pegfilgrastim) prescribing information to include data from a landmark Phase 3 study demonstrating the white blood cell booster helps protect patients with most types of cancer undergoing moderately myelosuppressive chemotherapy from infection, as manifested by febrile neutropenia (low white blood cell count with fever), one of the most serious side effects of chemotherapy.
Sep 16, 2005 - 10:13:00 AM
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Cancer
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Ligand Treatment of Treg Cells Enhanced Anti-Tumor Immunity
A special stretch of genetic material may turn off the immune suppression that stymies attempts to fight cancer with a vaccine, said researchers at Baylor College of Medicine (BCM) at Houston.
Sep 14, 2005 - 2:08:00 AM
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Cancer
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Metallic Iron based Magnetic Nanoparticles for Potential New Cancer Treatment
Virginia Commonwealth University researchers have created highly magnetized nanoparticles based on metallic iron that could one day be used in a non-invasive therapy for cancer in which treatment would begin at the time of detection.
Sep 8, 2005 - 1:23:00 AM
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Cancer
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Therapy
Potential Cancer Treatment by Magnetic Nanoparticles
Virginia Commonwealth University researchers have created highly magnetized nanoparticles based on metallic iron that could one day be used in a non-invasive therapy for cancer in which treatment would begin at the time of detection.
Aug 30, 2005 - 8:05:00 PM
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Cancer
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Pharmacotherapy
Celecoxib able to control chemotherapy resistant tumor cells
A close structural relative of the celebrated COX-2 inhibitor celecoxib (brand name: Celebrex) is a potent tumor fighter, able to wipe out tumor cells that are resistant to conventional chemotherapies, according to an interdisciplinary team of researchers from the University of Southern California.
Aug 30, 2005 - 7:23:00 PM
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Inhibiting EAT-2 with medications could boost NK cell activity
Dr. Andr� Veillette, a researcher at the Institut de recherches cliniques de Montr�al (IRCM), and his team will publish in the upcoming issue of the prestigious journal Nature Immunology of Nature Publishing Group, a discovery that could significantly advance the treatment of cancers and infectious diseases. Current treatments frequently achieve only limited results with these types of diseases, which affect hundreds of thousands of Canadians.
Aug 29, 2005 - 10:57:00 PM
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