XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
  AIDS
  Influenza
  MRSA
  Tuberculosis
  Shigella
  HCV
  SARS
  Ebola
  Dengue
  Malaria
   Plasmodium
  Pertussis
  Mumps
  Prion Diseases
  Small Pox
  Anthrax
  Leishmaniasis
 Respiratory Medicine
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
 
 India
Search

Last Updated: Nov 18, 2006 - 12:32:53 PM

Malaria Channel
subscribe to Malaria newsletter

Latest Research : Infectious Diseases : Malaria

   DISCUSS   |   EMAIL   |   PRINT
LMP-420 reduces endothelial cell activation in cerebral malaria
Aug 23, 2005 - 8:11:00 PM, Reviewed by: Dr.

The authors caution that the experimental in vitro results do not necessarily predict potential efficacy in either animal models or humans, especially since in their model the LMP-420 had to be given before the disease process was established.

 
In a paper published online in PLoS Medicine researchers from Marseille describe the effects of a new compound that may be a future treatment for patients with cerebral malaria. The compound�XLMP-420�Xinhibits two of the molecules produced in the brain when affected by cerebral malaria.

Cerebral malaria is a complication that can occur in malaria caused by the parasite Plasmodium falciparum. In cerebral malaria, the parasites infect the red blood cells that accumulate within the very small capillaries that flow through the tissues of the brain. Even when treated, cerebral malaria has a fatality rate of 15% or more.

Using an in vitro model of cerebral malaria, the researchers, led by George Grau, found that LMP-420 potently reduced the activation of endothelial cells (cells that line the small blood vessels), how well malaria-infected red blood cells stuck to these endothelial cells, and the release of micro particles from the same cells�Xthree major features of cerebral malaria.

The authors caution that the experimental in vitro results do not necessarily predict potential efficacy in either animal models or humans, especially since in their model the LMP-420 had to be given before the disease process was established. Nevertheless, this avenue of research is a promising one to explore further.
 

- Citation: Wassmer SC, Cianciolo GJ, Combes V, Grau GE (2005) Inhibition of endothelial activation: A new way to treat cerebral malaria? PLoS Med 2(9): e245.
 

http://www.plosmedicine.org/

 
Subscribe to Malaria Newsletter
E-mail Address:

 

All works published in PLoS Medicine are open access. Everything is immediately available without cost to anyone, anywhere�Xto read, download, redistribute, include in databases, and otherwise use subject only to the condition that the original authorship and source are properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.

Related Malaria News

Retina can provide a very reliable way of diagnosing cerebral malaria
New findings could lead to vaccine for severe malaria
AgDscam gene Holds the Key to Broad-Based Pathogen Recognition
Genes responsible for malaria parasite's survival pin pointed
Mosquito immune system examined
The Haptoglobin Genotype Connection with Childhood Anemia in a Malaria-Endemic Region
Mosquitoes that could help combat malaria!
Malaria parasite plasmodium impairs key immune system cells
Modeling the Impact of Intermittent Preventative Treatment on the Spread of Drug-Resistant Malaria
Global warming trend may contribute to malaria's rise


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us