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Last Updated: Nov 18, 2006 - 12:32:53 PM |
Latest Research
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Nephrology
Kidney stones? Have some orange juice!!!
A daily glass of orange juice can help prevent the recurrence of kidney stones better than other citrus fruit juices such as lemonade, researchers at UT Southwestern Medical Center have discovered.
Sep 1, 2006 - 5:14:00 PM
Latest Research
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Nephrology
NOTCH2 gene mutations linked to Alagille syndrome
In a finding that may have broader implications for understanding kidney disorders, genetics researchers at The Children's Hospital of Philadelphia have identified a second gene that gives rise to Alagille syndrome, a genetic developmental disease that affects multiple organs. The Children's Hospital team previously discovered the first gene associated with this disease.
Aug 1, 2006 - 1:30:00 PM
Latest Research
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Nephrology
Fetal hydronephrosis mystery solved
Researchers seeking insights into kidney failure in human infants have located the source of a 30-year-old mystery mutation that causes similar problems in a mouse line. Scientists have known of the mouse line's naturally occurring mutation since the early 1970s. Researchers at Washington University School of Medicine in St. Louis are the first to identify the mutated gene, allowing them to determine the mutation's effects and the origins of the disease.
May 3, 2006 - 12:14:00 AM
Latest Research
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Nephrology
Alport Syndrome: From Pathogenesis to a Potential Therapy
In 1927, Cecil Alport described a family in which affected individuals developed progressive kidney failure, deafness, and sometimes eye problems. Alport syndrome, although it affects only one in 50,000 live births in the United States, is the second most commonly inherited reason for kidney failure. It is caused by mutations in the genes that encode type IV collagen, a structural component of the thin, sheet-like basement membrane that covers the glomeruli, the kidney's filtration units. The glomerular basement membrane (GBM) normally filters fluid and small molecules (but not proteins or red blood cells) from the capillaries in the glomeruli into the urine, but in Alport syndrome, the collagen scaffold of the GBM is defective and, over time, the GBM splits and thins. The first symptom of Alport syndrome is blood in the urine (hematuria), followed by proteinuria and progressive renal failure as scar tissue (fibrotic tissue) forms around the glomeruli. The syndrome has no specific treatment, but kidney transplantation is usually successful in patients with end-stage kidney failure.
Mar 8, 2006 - 5:07:00 AM
Latest Research
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Nephrology
Meckel-Gruber syndrome gene identified- a help to understand polycystic kidney disease
An international research collaboration led by Mayo Clinic has identified a new gene involved in causing the inherited kidney disorder, Meckel-Gruber syndrome (MKS). Children with MKS have central nervous system deformities as well as abnormal cysts in their kidneys, and usually die shortly after birth.
Jan 17, 2006 - 2:10:00 AM
Latest Research
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Nephrology
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Dialysis
Dialysis patients may be overmedicated
Changes in a widely used assay (blood test) for parathyroid hormone (PTH) have made its use with the established guidelines for end stage renal disease clinical management both inappropriate and potentially harmful to patients. This research is published in the journal Seminars in Dialysis.
Nov 30, 2005 - 3:35:00 PM
Latest Research
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Nephrology
Mycophenolate mofetil may be more effective in inducing lupus nephritis remission
Treating lupus patients suffering from kidney inflammation with a medicine known as mycophenolate mofetil may be more effective in inducing remission than treating them with the standard regimen of intravenous cyclophosphamide (Cytoxan), a new clinical trial indicates. The study, published in Thursday�s issue (Nov. 24) of the New England Journal of Medicine, also showed that mycophenolate mofetil produced fewer complications, researchers found.
Nov 25, 2005 - 6:22:00 AM
Latest Research
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Nephrology
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Dialysis
Dialysis patients often have close family members also on dialysis - Study
Nearly one-fourth of all dialysis patients have a close relative on dialysis, researchers at Wake Forest University Baptist Medical Center, and others, report in the current online edition of the American Journal of Nephrology. The researchers suggest screening other relatives for undetected kidney disease.
Nov 2, 2005 - 12:12:00 PM
Latest Research
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Nephrology
Prognosis Improving For Diabetics With End Stage Renal Disease
Patients with type 1 diabetes have an improved prognosis with regard to end-stage renal disease over the past four decades, and it appears the incidence of end-stage renal disease is lower than previously estimated, according to a study in the October 12 issue of JAMA.
Oct 14, 2005 - 9:55:00 PM
Latest Research
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Nephrology
Osmolytes critical to survival of kidney cells
Researchers at the University of Texas Medical Branch at Galveston (UTMB) have developed a new way to predict the ability of certain small molecules to protect proteins in the cells of a wide variety of organisms living in extreme environments. The technique, described in a paper published online Oct. 7 in the Proceedings of the Natural Academy of Sciences (PNAS), is a method of calculating the stabilizing effect on cellular proteins by small organic molecules called "osmolytes." It could have implications for the study of Alzheimer's disease, cystic fibrosis, kidney disease and stabilizing protein drugs.
Oct 8, 2005 - 5:40:00 AM
Latest Research
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Nephrology
Study Examines Global Prevalence Of Kidney Failure Among Critically Ill Patients
A multinational study has found that 5 to 6 percent of patients in intensive care units experience acute kidney failure, and about 60 percent of these patients die in the hospital, according to an article in the August 17 issue of JAMA.
Aug 17, 2005 - 9:59:00 PM
Latest Research
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Nephrology
"gold standard" of open surgery for kidney tumors should remain the first choice
Urologists often view less-invasive surgery techniques as more desirable for the patient, but in a study of open nephron-sparing surgeries (NSS) from 1985 to 2001 at Mayo Clinic, researchers found that the "gold standard" of open surgery for kidney tumors should remain the first choice for many patients. The study appears online in The Journal of Urology.
Aug 10, 2005 - 12:22:00 PM
Latest Research
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Nephrology
Chronic Kidney Disease Associated with "Benign" Prostate Obstruction
Men who experience signs and symptoms of a prostate obstruction resulting from benign prostatic hyperplasia (BPH) are three times more likely than other men to develop chronic kidney disease, according to findings of a Mayo Clinic study published in this month's edition of Kidney International.
Jun 29, 2005 - 1:00:00 PM
Latest Research
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Nephrology
Unique therapeutic strategy for Chronic Kidney Disease (CKD)
Researchers at Oregon Health & Science University's Doernbecher Children's Hospital have uncovered a unique therapeutic strategy to combat cachexia -- severe malnutrition and physical wasting away -- in children and adults with chronic kidney disease (CKD). The study is published in the June issue of the Journal of Clinical Investigation.
Jun 12, 2005 - 5:42:00 AM
Latest Research
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Nephrology
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Dialysis
Hemodialysis causes antioxidant loss leading to long-term complications
An article published in Hemodialysis International discusses the role of oxidative stress (OS) in dialysis patients, an imbalance which can result in long-term health problems. Potential therapeutic options to restore balance in patients are also reviewed.
Apr 8, 2005 - 1:34:00 AM
Latest Research
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Nephrology
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Dialysis
Oxidative Stress in Dialysis Patients can Lead to Long-Term Health Problems
An article published in Hemodialysis International discusses the role of oxidative stress (OS) in dialysis patients, an imbalance which can result in long-term health problems. Potential therapeutic options to restore balance in patients are also reviewed.
Apr 3, 2005 - 10:04:00 AM
Latest Research
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Nephrology
KCP enhances signals from bone morphogenetic proteins that control kidney development and disease
Scientists have identified a new and unusual protein that reduces, in laboratory mice, kidney damage caused by chronic renal disease and acute toxic injuries.
Mar 29, 2005 - 3:18:00 PM
Latest Research
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Nephrology
Sulodexide Gelcaps : An Oral Heparinoid for the Treatment of Diabetic Nephropathy Gets Ready for Phase 3-4 Trial
Keryx Biopharmaceuticals, Inc. announced today that it has finalized a Special Protocol Assessment (SPA) agreement with the Food and Drug Administration (FDA) for the Phase 3 and Phase 4 clinical trials of KRX-101 (sulodexide gelcaps), the Company's drug candidate for the treatment of diabetic nephropathy.
Mar 17, 2005 - 8:03:00 AM
Latest Research
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Nephrology
Age Should Not Be A Limiting Factor for Kidney Transplantation
Growing evidence suggests that age alone shouldn�t prevent older adults from being organ donors � or having a kidney transplant themselves � according to researchers at Wake Forest University Baptist Medical Center. The findings could help alleviate a serious shortage of organs for transplantation.
Mar 15, 2005 - 1:54:00 PM
Latest Research
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Nephrology
Vitamin D May Significantly Improve Survival in Dialysis Patients
The administration of intravenous vitamin D appears to significantly improve the survival of patients on dialysis, according to a study that will be published in the April Journal of the American Society of Nephrology and has been released ahead of print on the journal's website. Vitamin D injections are currently recommended only for dialysis patients with elevated levels of parathyroid hormone, but the report from a Massachusetts General Hospital (MGH)-based research group suggests that the treatment might help most dialysis patients live longer.
Mar 13, 2005 - 8:34:00 AM
Latest Research
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Nephrology
BMP-7 Prevents Renal Osteodystrophy and Vascular Calcification Associated with Chronic Renal Disease
The investigators demonstrate that BMP-7 treatment prevents renal osteodystrophy and vascular calcification by stimulating the rate of skeletal mineralization, thereby diverting mineral that might have been deposited inappropriately in the blood vessels.
Mar 13, 2005 - 8:26:00 AM
Latest Research
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Nephrology
LEA29Y (belatacept) effectively preserves kidneys during transplants
Emory University physician-researchers in Atlanta have shown an investigational medication, known as LEA29Y (belatacept), is effective in preserving transplanted kidney function while at the same time avoiding the toxic side effects that are common in the currently used long-term, immunosuppressive transplant medications. The pre-clinical research conducted with nonhuman primates at the Yerkes National Primate Research center was an important step in establishing human clinical trials to develop an effective alternative to current anti-rejection therapies.
Feb 23, 2005 - 8:04:00 PM
Latest Research
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Nephrology
Why Blood Glucose Control Matters for the Kidney
One of the most common and most serious complications of both type 1 and type 2 diabetes is diabetic nephropathy. It occurs in around 30% of patients with type 1 diabetes and 10% to 40% of patients with type 2 diabetes. Diabetic nephropathy is the leading cause of renal failure in the developed world. The main effect of diabetic nephropathy is proteinuria, initially in very small amounts but which increases, leading to nephrotic syndrome and end-stage renal disease in most cases.
Feb 22, 2005 - 9:50:00 PM
Latest Research
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Nephrology
Amitriptyline to be tested for painful bladder syndrome
PBS is defined by symptoms--frequent urination day and night and increasing pain as the bladder fills--according to the International Continence Society. The syndrome includes IC, which has been estimated to affect as many as 700,000 people, mostly women. Estimates for PBS vary widely, but as many as 10 million people may suffer from this condition.
Feb 18, 2005 - 4:29:00 PM
Latest Research
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Nephrology
Obese kidney donors are as safe as other donors
In a retrospective study of more than 500 patients, at an average of eleven months after kidney donation, Mayo doctors found obese donors did not experience more problems than non-obese donors. However, prior to donation, obese patients were at greater risk for cardiovascular disease based on blood pressure and cholesterol levels, compared to normal weight donors. Despite the findings, the study emphasizes the importance of following obese patients for a longer time before drawing any long-term conclusions.
Feb 18, 2005 - 4:24:00 PM
Latest Research
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Nephrology
Potential therapy may stop Kidney failure
The research, which is published in the March issue of the Journal of Clinical Investigation, shows that injection of a protein, known as Ngal, can protect mice from renal failure, suggesting its great potential as a therapeutic tool for humans.
Feb 17, 2005 - 9:31:00 PM
Latest Research
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Nephrology
Second-Generation Lanthanum-Based Phosphate Binders Have Potential Role in Treatment of Hyperphosphatemia in End-Stage Renal Disease
These novel non-aluminum, non-calcium phosphate binders which utilize Altair's proprietary lanthanum nanomaterial technology have the potential to treat hyperphosphatemia, i.e., high phosphorus levels in blood, in patients with end-stage renal disease (ESRD) and chronic kidney disease (CKD), with potentially as little as one tablet per meal while currently approved therapies require as many as several tablets per meal.
Feb 1, 2005 - 9:15:00 AM
Latest Research
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Nephrology
Understanding acid sensing in the kidney
The normal daily diet generates volatile acid (carbon dioxide) and nonvolatile acid (hydrogen ions) from carbohydrate and protein metabolism, respectively, and the kidney is responsible for maintaining an acid-base balance by excreting these acids. In this issue of the Journal of Clinical Investigation, Patricia Preisig and colleagues from the University of Texas Southwestern Medical Center have identified the kidney's elusive acid sensor. The authors examined opossum kidney cells cultured under acidic conditions and found that a 24-hour exposure to acid activates the enzyme Pyk2, which then binds to the proto-oncogene c-Src, causing c-Src activation and subsequent activation of signaling pathways that increase production of NHE3, the molecule at the surface of renal proximal tubule cells in the kidney that release hydrogen ions from the cell.
Dec 16, 2004 - 5:53:00 PM
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