XML Feed for RxPG News   Add RxPG News Headlines to My Yahoo!   Javascript Syndication for RxPG News

Research Health World General
 
  Home
 
 Latest Research
 Cancer
 Psychiatry
 Genetics
 Surgery
 Aging
 Ophthalmology
 Gynaecology
 Neurosciences
 Pharmacology
 Cardiology
 Obstetrics
 Infectious Diseases
 Respiratory Medicine
  Asthma
  COPD
  Cystic Fibrosis
 Pathology
 Endocrinology
 Immunology
 Nephrology
 Gastroenterology
 Biotechnology
 Radiology
 Dermatology
 Microbiology
 Haematology
 Dental
 ENT
 Environment
 Embryology
 Orthopedics
 Metabolism
 Anaethesia
 Paediatrics
 Public Health
 Urology
 Musculoskeletal
 Clinical Trials
 Physiology
 Biochemistry
 Cytology
 Traumatology
 Rheumatology
 
 Medical News
 Health
 Opinion
 Healthcare
 Professionals
 Launch
 Awards & Prizes
 
 Careers
 Medical
 Nursing
 Dental
 
 Special Topics
 Euthanasia
 Ethics
 Evolution
 Odd Medical News
 Feature
 
 World News
 Tsunami
 Epidemics
 Climate
 Business
Search

Last Updated: Aug 19th, 2006 - 22:18:38

COPD Channel
subscribe to COPD newsletter

Latest Research : Respiratory Medicine : COPD

   DISCUSS   |   EMAIL   |   PRINT
Breathing Heliox 28 significantly improve the exercise performance in COPD
Apr 15, 2006, 18:48, Reviewed by: Dr. Sanjukta Acharya

"The changes in endurance exercise and reductions in breathlessness we report while breathing increased inspired oxygen or heliox gas mixtures are substantial, being at least comparable to those achieved with current bronchodilator therapy, pulmonary rehabilitation or even lung volume reduction surgery."

 
Breathing a special gas mixture may significantly improve the exercise performance of individuals with severe chronic obstructive pulmonary disease (COPD). During an endurance walking test, the patients found that they could improve their walking distance by 64 percent with less shortness of breath.

Elizabeth A. Laude, Ph.D., of the University of Sheffield in the United Kingdom, and seven associates investigated the effects of varying oxygen and helium levels in the air breathed during exercise by 82 patients who had severe, but stable COPD.

The investigators tested four different gas mixtures with the patients: 72 percent helium and 28 percent oxygen (Heliox28); 79 percent helium and 21 percent oxygen (Heliox21); 72 percent nitrogen and 28 percent oxygen (Oxygen28); and 79 percent nitrogen and 21 percent oxygen (medical air).

"Patients walked significantly further while breathing Heliox 28 than with either Heliox 21 or Oxygen 28," said Dr. Laude.

By replacing the nitrogen with normal supplementary oxygen with lower density helium gas, the researchers hoped that they might reduce airway resistance and improve the participants' respiratory gas exchange.

"COPD is associated with impaired exercise capacity, which contributes significantly to a reduced quality of life in these patients," said Dr. Laude.

COPD results from persistent obstruction of the airways associated with either severe emphysema or chronic bronchitis. In emphysema, the tiny air sacs of the lung (alveoli) become enlarged and their walls are destroyed. In chronic bronchitis, the bronchial glands enlarge, causing a chronic cough and excess mucus. Ten to 15 percent of all smokers develop COPD as a result of irritants in tobacco that cause inflammation of the alveoli.

During the exercise test, the gas mixtures were administered through face masks with a special valve for the incoming gas. An investigator carried a gas cylinder with the mixture while walking beside the patient.

Individuals with the worst lung function test results showed the greatest benefit from the special mixtures.

"Although the recent American Thoracic Society/European Respiratory guidelines had recognized COPD is a preventable and treatable condition, it is still regarded by many as one in which significant improvement is not possible," said Dr. Laude. "Our data shows this is not the case. The changes in endurance exercise and reductions in breathlessness we report while breathing increased inspired oxygen or heliox gas mixtures are substantial, being at least comparable to those achieved with current bronchodilator therapy, pulmonary rehabilitation or even lung volume reduction surgery."

In an editorial on the article in the same issue of the journal, Jadwiga A. Wedzicha, M.D., of University College London in the United Kingdom, tried to answer a fundamental question raised by the study. He wrote: "Can these findings be applied in clinical practice? The most promising use of Heliox mixtures would be as an adjunct of pulmonary rehabilitation in patients with severe COPD who are still disabled by dyspnea and are unable to achieve full benefits of training despite pharmacologic treatment and ambulatory oxygen therapy. Use of Heliox with rehabilitation needs to be tested in large controlled studies with appropriate outcome measures. Heliox is also easier for the patient to tolerate during exercise than noninvasive ventilation, but the two treatments will need formal comparisons. However, before any further development in Heliox therapy for COPD, improved methods of delivery of Heliox to the hospital clinic and community would need to be developed. Recent data shows that despite benefits in patients with COPD, compliance with ambulatory oxygen in the community is relatively poor."
 

- The results appear in the April 15th issue of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
 

www.thoracic.org

 
Subscribe to COPD Newsletter
E-mail Address:

 



Related COPD News

COPD patients using beta-agonist inhalers are at risk
Beta-agonists more than double death rate in COPD patients
Lung function test underused in patients with COPD
Wrinkles clue to risk of progressive lung disease (COPD)
Antibiotics reduce risk of dying from COPD attack by 77 percent
Women with chronic obstructive pulmonary disease (COPD) fare worse than men
Breathing Heliox 28 significantly improve the exercise performance in COPD
Combined treatment cuts inflammatory cells in chronic obstructive pulmonary disease
COPD is slated to become world's biggest killer by 2020 - WHO
Study Shows Benefits of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease


For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 

© Copyright 2004 onwards by RxPG Medical Solutions Private Limited
Contact Us